REFMAC

TLS
RANGE  'A   1.' 'A 447.' ALL
ORIGIN    21.7878  37.6947  37.4617
T     0.3509   0.3526   0.3320  -0.0282  -0.0167  -0.0107
L     0.9108   1.1472   0.8157  -0.4830  -0.2282  -0.0534
S     0.0159  -0.0346  -0.0386  -0.0471  -0.1767   0.0437   0.0773   0.1463